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Authors: Rasika S. Phansalkar, Charlotte Simmler, Jonathan BissonORCID , Shao-Nong Shen, David C. Lankin, James B. McAlpine, Matthias Niemitz, Guido F. PauliORCID
Journal: Journal of Natural Products (RoMEO status: White)
Subjects: Pharmacognosy Phytochemistry NMR qNMR HiFSA
Chemical standardization, along with morphological and DNA analysis ensures the authenticity and advances the integrity evaluation of botanical preparations. Achievement of a more comprehensive, metabolomic standardization requires simultaneous quantitation of multiple marker compounds. Employing quantitative 1H NMR (qHNMR), this study determined the total isoflavone content (TIfCo; 34.5–36.5% w/w) via multimarker standardization and assessed the stability of a 10-year-old isoflavone-enriched red clover extract (RCE). Eleven markers (nine isoflavones, two flavonols) were targeted simultaneously, and outcomes were compared with LC-based standardization.
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Authors: Jonathan BissonORCID , Charlotte Simmler, Shao-Nong Chen, J. Brent Friesen, David C. Lankin, James McAlpine, Guido F. PauliORCID
Journal: Natural Product Reports (RoMEO status: Yellow)
Subjects: Fundamental research NMR raw data
The notion of data transparency is gaining a strong awareness among the scientific community. The availability of raw data is actually regarded as a fundamental way to advance science by promoting both integrity and reproducibility of research outcomes. Particularly, in the field of natural product and chemical research, NMR spectroscopy is a fundamental tool for structural elucidation and quantification (qNMR). As such, the accessibility of original NMR data, i.e., Free Induction Decays (FIDs), fosters transparency in chemical research and optimizes both peer review and reproducibility of reports by offering the fundamental tools to perform efficient structural verification.
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