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Authors / James G. Graham >

authors Adriano Rutz ORCID , Maria Sorokina , Jakub Galgonek , Daniel Mietchen , Egon Willighagen , Arnaud Gaudry , James G. Graham ORCID , Ralf Stephan , Roderic Page , Jiří Vondrášek , Christoph Steinbeck ORCID , Guido F. Pauli ORCID , Jean-Luc Wolfender ORCID , Jonathan Bisson ORCID , Pierre-Marie Allard ORCID
journal bioRxiv
subjects Wikidata Natural products Databases Chemoinformatics
Contemporary bioinformatic and chemoinformatic capabilities hold promise to reshape knowledge management, analysis and interpretation of data in natural products research. Currently, reliance on a disparate set of non-standardized, insular, and specialized databases presents a series of challenges to data access, either within the discipline or to integration and interoperability between related domains. The fundamental elements of exchange are referenced structure-organism pairs that establish relationships between distinct molecular structures and the living organisms from which they were identified.
categories publications science

Publication / The Essential Medicinal Chemistry of Cannabidiol (CBD) OpenAccess >

authors Kathryn M. Nelson ORCID , Jonathan Bisson ORCID , Gurpreet Singh ORCID , James G. Graham ORCID , Shao-Nong Chen ORCID , J. Brent Friesen ORCID , Jayme L. Dahlin ORCID , Matthias Niemitz ORCID , Michael A. Walters ORCID , Guido F. Pauli ORCID
journal Journal of Medicinal Chemistry (RoMEO status: White)
subjects Pharmacognosy IMPS Artifacts Cannabis
This Perspective of the published essential medicinal chemistry of cannabidiol (CBD) provides evidence that the popularization of CBD-fortified or CBD-labeled health products and CBD-associated health claims lacks a rigorous scientific foundation. CBD’s reputation as a cure-all puts it in the same class as other “natural” panaceas, where valid ethnobotanicals are reduced to single, purportedly active ingredients. Such reductionist approaches oversimplify useful, chemically complex mixtures in an attempt to rationalize the commercial utility of natural compounds and exploit the “natural” label.
categories publications science