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Authors: Kathryn M. Nelson, Jayme L. Dahlin, Jonathan BissonORCID , James Graham, Guido F. PauliORCID , Michael A. Walters
Journal: Journal of Medicinal Chemistry (RoMEO status: White)
Subjects: Pharmacognosy Phytochemistry Curcumin IMPs PAINS Review
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases.
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Authors: Jonathan BissonORCID , James McAlpine, J. Brent Friesen, Shao-Nong Chen, James Graham, Guido F. PauliORCID
Journal: Journal of Medicinal Chemistry (RoMEO status: White)
Subjects: Pharmacognosy Phytochemistry Perspectives Fundamental research IMP bioactivity data mining NAPRALERT
High-throughput biology has contributed a wealth of data on chemicals, including natural products (NPs). Recently, attention was drawn to certain, predominantly synthetic, compounds that are responsible for disproportionate percentages of hits but are false actives. Spurious bioassay interference led to their designation as pan-assay interference compounds (PAINS). NPs lack comparable scrutiny, which this study aims to rectify. Systematic mining of 80+ years of the phytochemistry and biology literature, using the NAPRALERT database, revealed that only 39 compounds represent the NPs most reported by occurrence, activity, and distinct activity.
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