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# / Langmuir

Authors: Cristina M.P. Vidal, Ariene A. Leme, Thaiane R. Aguiar, Rasika Phansalkar, Joo-Won Nam, Jonathan BissonORCID , James McAlpine, Shao-Nong Chen, Guido F. PauliORCID , Ana Bedran-Russo
Journal: Langmuir (RoMEO status: White)
Subjects: Pharmacognosy Phytochemistry Dentistry Polyphenols NMR
Proanthocyanidins (PACs) are secondary plant metabolites that mediate nonenzymatic collagen cross-linking and enhance the properties of collagen based tissue, such as dentin. The extent and nature of cross-linking is influenced by the composition and specific chemical structure of the bioactive compounds present in certain PAC-rich extracts. This study investigated the effect of the molecular weight and stereochemistry of polyphenol compounds on two important properties of dentin, biomechanics, and biostability. For that, purified phenols, a phenolic acid, and some of its derivatives were selected: PAC dimers (A1, A2, B1, and B2) and a trimer (C1), gallic acid (Ga), its esters methyl-gallate (MGa) and propyl-gallate (PGa), and a pentagalloyl ester of glucose (PGG).
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Categories: publications