Authors: Merian Nassra , Stéphanie Krisa , Yorgos Papastamoulis , Gilbert Deccaux Kapche , Jonathan Bisson , Caroline André , Jan-Pieter Konsman , Jean-Marie Schmitter , Jean-Michel Mérillon , Pierre Waffo-Téguo
Journal: Planta Medica (RoMEO status: Blue) 79(11), 966-970, (2013)
Microglia-driven inflammatory processes are thought to play an important role in ageing and several neurological disorders. Since consumption of a diet rich in polyphenols has been associated with anti-inflammatory and neuroprotective effects, we studied the effects of twenty-five stilbenoids isolated from Milicia excelsa, Morus alba, Gnetum africanum, and Vitis vinifera. These compounds were tested at 5 and 10 µM on BV-2 microglial cells stimulated with bacterial lipopolysaccharide. Ten stilbenoids reduced lipopolysaccharide-induced nitric oxide production at 5 and/or 10 µM. Two tetramers, E-vitisin A and E-vitisin B, were the most effective molecules. Moreover, they attenuated the expression of the inducible NO synthase protein and gene.