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authors Kathryn M. Nelson ORCID , Jayme L. Dahlin ORCID , Jonathan Bisson ORCID , James Graham , Guido F. Pauli ORCID , Michael A. Walters ORCID
journal Journal of Medicinal Chemistry (RoMEO status: White)
subjects Pharmacognosy Phytochemistry Curcumin IMPs PAINS Review
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases.
categories publications science