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authors Mary P. Choules ORCID , Jonathan Bisson ORCID , Wei Gao , David C. Lankin ORCID , James B. McAlpine ORCID , Matthias Niemitz ORCID , Birgit U. Jaki ORCID , Scott G. Franzblau ORCID , Guido F. Pauli ORCID
journal Journal of Organic Chemistry (RoMEO status: White)
subjects NMR Quality control Peptide Sequencing
Ensuring identity, purity, and reproducibility are equally essential during synthetic chemistry, drug discovery, and for pharmaceutical product safety. Many peptidic APIs are large molecules that require considerable effort for integrity assurance. This study builds on quantum mechanical 1H iterative Full Spin Analysis (HiFSA) to establish NMR peptide sequencing methodology that overcomes the intrinsic limitations of principal compendial methods in identifying small structural changes or minor impurities that affect effectiveness and safety.
categories publications science