authors
Merian Nassra
,
Stéphanie Krisa
,
Yorgos Papastamoulis
,
Gilbert Deccaux Kapche
,
Jonathan Bisson
,
Caroline André
,
Jan-Pieter Konsman
,
Jean-Marie Schmitter
,
Jean-Michel Mérillon
,
Pierre Waffo-Téguo
journal Planta Medica (RoMEO status: Blue)
subjects Pharmacognosy Phytochemistry Vine Wine Stilbenoids Polyphenols Bioactivity
Read More...
journal Planta Medica (RoMEO status: Blue)
subjects Pharmacognosy Phytochemistry Vine Wine Stilbenoids Polyphenols Bioactivity
Microglia-driven inflammatory processes are thought to play an important role in ageing and several neurological disorders. Since consumption of a diet rich in polyphenols has been associated with anti-inflammatory and neuroprotective effects, we studied the effects of twenty-five stilbenoids isolated from Milicia excelsa, Morus alba, Gnetum africanum, and Vitis vinifera. These compounds were tested at 5 and 10 µM on BV-2 microglial cells stimulated with bacterial lipopolysaccharide. Ten stilbenoids reduced lipopolysaccharide-induced nitric oxide production at 5 and/or 10 µM. Two tetramers, E-vitisin A and E-vitisin B, were the most effective molecules. Moreover, they attenuated the expression of the inducible NO synthase protein and gene.